The tractor-trailer sprawled across Fairview Ave, closing the street between Curtis and Liberty for hours early Friday morning.
The driver of the pickup had to be extricated from the vehicle by Boise firefighters and was sent to Saint Als hospital with non life threatening injuries.
Troopers said the driver of the tractor-trailer is okay.
Diesel fuel and milk the truck was carrying covered the street. Crews worked to make sure the diesel wasn't a safety issue once the street gets reopened.
"The diesel the way it is right now isn't that much of a hazard just because there isn't any flammable sources around it, and that's why the fire department is here, to make sure that part of it is safe, before we can get the rest of the Fidel offloaded off the diesel into containers," said Idaho State Police Corporal Matthew Sly.
Boise police officers said Fairview Ave should be reopened around 9 a.m.
Alcohol may be a factor in the crash