Bonneville County Sheriff Paul Wilde says the seizure Thursday is one of the biggest so far this year.
Police took into custody 34-year-old Alejandro Martinez-Zavala, 40-year-old Miguel Guiterrez-Munoz, and 36-year-old Ramon Meraz-Gallegos.
They face charges of trafficking of methamphetamine and possession of methamphetamine.
The investigation by the Bonneville County Sheriff's Office, Idaho Falls Police Department, Idaho State Police, Bureau of Homeland Security, FBI and Immigration Customs Enforcement found the three selling large quantities of drugs in the community.
In the raid on Thursday, police seized 17 pounds of meth, about 2.5 pounds of marijuana and 46 grams of cocaine.
Police also seized an AK-47 an $8,300 in cash.