OSP says that the women were driving on I-84 in Malheur County last Wednesday when they failed to signal lanes changes and were pulled over by a trooper.
During the investigation, OSP says the trooper found the heroin hidden in two gift baskets in the trunk of the car.
Officials estimate that the heroin is worth $200,000.
Sonla Marquez-Lozano, 22, and Yedid Zamudio-Vazquez, 20, were arrested and charged with unlawful possession and distribution of a controlled substance - heroin.
They have been booked into the Malheur County Jail.