The fire was at a home on Sunrise Rim Drive, near Vista Avenue.
Fire crews said when they arrived on the scene, the flames were burning on the back side of the house, but quickly spread to the entire structure.
The flames were so strong and intense that once crews made sure no one was inside they had to go into a defensive mode for safety of the fire fighters.
"We've gone from an offensive operation to a defensive operation cause of such heavy fire involvement in the structure," said Battalion Chief Tom Pawek of Boise Fire Department. "So all of our resources are outside the structure and eventually we will be able to get back inside to finish the mop up."
Firefighters said the house was destroyed by the fire.
Crews say the fire also spread into brush behind the house and burned down near the New York Canal.
Firefighters say they were able to get a perimeter set around the structure and were able to keep the flames away from neighboring buildings.
No one was home at the time of the blaze, but two dogs who were inside and neighbors helped them get out safely. No injuries were reported.
Fire investigators were on scene over night trying to find a cause of the blaze, but said it's undetermined.