The Seattle rap duo won four Grammy Awards so far Sunday, including best new artist and rap album for "The Heist," beating efforts from Kendrick Lamar, Jay Z, Kanye West and Drake.
"Wow, we're here on the stage right now," said Macklemore, thanking fans first, then his fiance and team. "I want to say we made this album without a record label, we made it independently and we appreciate all the support."
The duo performed the gay-acceptance hit "Same Love," and 33 couples - some same-sex - got married in the middle in the performance as Queen Latifah officiated.
"You can call me Queen Commish for a little longer," she joked backstage Sunday night.
Madonna joined in wearing an all-white suit and hat, and sang "Open Your Heart" and some of "Same Love" with Mary Lambert. Keith Urban cried and Katy Perry caught a bouquet during the performance.
Joining Macklemore on the song were Mary Lambert, Trombone Shorty and Madonna, who wore an all-white cowboy suit and carried a cane.
Latifah said she's not an ordained minister and her special powers expired at midnight.
"It was something I took very seriously," she said. "That is someone's life commitment to one another, you want to make sure you do it right. That's what sunk in for me."
Macklemore & Lewis' Grammy wins, which include best rap song and rap performance for "Thrift Shop," come after the Grammy rap committee almost ousted the group from its categories.
A source told The Associated Press that the rap committee rejected the duo, but that was later overruled by the general Grammy committee. The rap committee felt Macklemore & Lewis should qualify for the pop awards instead because of their massive success on Top 40 radio. The source, who attended the general Grammy meeting, spoke on the condition of anonymity because the meeting was private.
Photos: Inside the Grammy Awards >>>