Lohan's lawsuit was filed Wednesday in a Manhattan court. "Grand Theft Auto V" game maker Take-Two Interactive Software Inc. and subsidiary Rockstar Games declined to comment.
"Grand Theft Auto V" was released in September. Sales topped $800 million on its first day.
Lohan's suit says a character named Lacey Jonas is an "unequivocal" reference to the "Mean Girls" and "Freaky Friday" star.
The suit says Lohan's image, voice and styles from her clothing line are depicted. It says the game features West Hollywood's Chateau Marmont hotel, where Lohan once lived.
The character also seeks help skirting paparazzi.